the p250gap gene is associated with risk for schizophrenia and schizotypal personality traitsp250gap基因与精神分裂症的风险和分裂型人格特质.pdfVIP

The p250GAP Gene Is Associated with Risk for Schizophrenia and Schizotypal Personality Traits Kazutaka Ohi1,2,3, Ryota Hashimoto1,2,4*, Takanobu Nakazawa5,6, Takeya Okada1,2, Yuka Yasuda1,2, 1,2,7 1,2 7 1 1 Hidenaga Yamamori , Motoyuki Fukumoto , Satomi Umeda-Yano , Masao Iwase , Hiroaki Kazui , 5 6 1,4 Tadashi Yamamoto , Masanobu Kano , Masatoshi Takeda 1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, 2 Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan, 3 National Hospital Organization, Yamato Mental-Medical Center, Nara, Japan, 4 Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan, 5 Division of Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 6 Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 7 Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan Abstract Background: Hypofunction of the glutamate N-Methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. p250GAP is a brain-enriched NMDA receptor-interacting RhoGAP. p250GAP is involved in spine morphology, and spine morphology has been shown to be altered in the post-mortem brains of patients with schizophrenia. Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several sus