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the role of osteoprotegerin in arthritisosteoprotegerin在关节炎的作用
Available online /content/5/5/239
Review
The role of osteoprotegerin in arthritis
Georg Schett, Kurt Redlich and Josef S Smolen
Department of Internal Medicine III, Division of Rheumatology, University of Vienna, Austria
Corresponding author: Georg Schett (e-mail: georg.schett@akh-wien.ac.at)
Received: 1 Jul 2003 Revisions requested: 28 Jul 2003 Revisions received: 30 Jul 2003 Accepted: 31 Jul 2003 Published: 8 Aug 2003
Arthritis Res Ther 2003, 5:239-245 (DOI 10.1186/ar990)
© 2003 BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362)
Abstract
Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests
that osteoclasts are essential for the formation of local bone erosions. Two essential regulators of
osteoclastogenesis have recently been described: the receptor-activator of nuclear factor kappa B
ligand, which promotes osteoclast maturation, and osteoprotegerin (OPG), which blocks
osteoclastogenesis. The present review summarizes the current knowledge on the role of osteoclasts
in local bone erosion. In addition, the role of OPG as a therapeutic tool to inhibit local bone erosion is
addressed. Finally, evidence for OPG as an inhibitor of systemic inflammatory bone loss is discussed.
Keywords: bone erosion, osteoclasts, osteoporosis, osteoprotegerin, rheumatoid arthritis
Local bone erosions in rheumatoid arthritis enzymes that degrade the extracellular matrix, such as
Rheumatoid arthritis (RA) is a highly osteodestructive matrix metalloproteinases, play a part in this pro
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