the stem cell marker cd133 associates with enhanced colony formation and cell motility in colorectal cancer干细胞标志物cd133 associates和增强的集落形成细胞运动性结肠直肠癌.pdfVIP

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the stem cell marker cd133 associates with enhanced colony formation and cell motility in colorectal cancer干细胞标志物cd133 associates和增强的集落形成细胞运动性结肠直肠癌.pdf

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the stem cell marker cd133 associates with enhanced colony formation and cell motility in colorectal cancer干细胞标志物cd133 associates和增强的集落形成细胞运动性结肠直肠癌

The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer 1,2 3 3 1 1 Tarek M. A. Elsaba , Luisa Martinez-Pomares , Adrian R. Robins , Simon Crook , Rashmi Seth , Darryl 1 4 4 5 1,6 Jackson , Amy McCart , Andrew R. Silver , Ian P. M. Tomlinson , Mohammad Ilyas * 1 Division of Pathology, School of Molecular Medical Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, 2 Department of Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, 3 Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, 4 Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, United Kingdom, 5 Molecular and Population Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, 6 Nottingham Digestive Diseases Centre–Biological Research Unit, Queen’s Medical Centre, Nottingham, United Kingdom Abstract CD133 is a membrane molecule that has been, controversially, reported as a CSC marker in colorectal cancer (CRC). In this study, we sought to clarify the expression and role of CD133 in CRC. Initially the size of the CD1332expressing (CD133+) population in eight well-described CRC cell lines was measured by flow cytometry and was found to range from 0% to .95%. The cell line HT29 has a CD133+ population of .95% and was chosen for functional evaluati