the tight junction associated signalling proteins zo-1 and zonab regulate retinal pigment epithelium homeostasis in mice紧密连接相关信号蛋白zo-1和zonab调节视网膜色素上皮细胞在小鼠体内平衡.pdfVIP

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the tight junction associated signalling proteins zo-1 and zonab regulate retinal pigment epithelium homeostasis in mice紧密连接相关信号蛋白zo-1和zonab调节视网膜色素上皮细胞在小鼠体内平衡.pdf

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the tight junction associated signalling proteins zo-1 and zonab regulate retinal pigment epithelium homeostasis in mice紧密连接相关信号蛋白zo-1和zonab调节视网膜色素上皮细胞在小鼠体内平衡

The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice 1,4. 1. 1 1 Anastasios Georgiadis , Marion Tschernutter , James W. B. Bainbridge , Kamaljit S. Balaggan , Freya 1 1 3 4 2 2 Mowat , Emma L. West , Peter M. G. Munro , Adrian J. Thrasher , Karl Matter , Maria S. Balda * , Robin R. Ali1,4* 1 Department of Genetics, UCL Institute of Ophthalmology, University College London, London, United Kingdom, 2 Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom, 3 Electron Microscopy Unit, UCL Institute of Ophthalmology, University College London, London, United Kingdom, 4 Molecular Immunology Unit, UCL Institute of Child Health, University College London, London, United Kingdom Abstract Cell-cell adhesion regulates the development and function of epithelia by providing mechanical support and by guiding cell proliferation and differentiation. The tight junction (TJ) protein zonula occludens (ZO)-1 regulates cell proliferation and gene expression by inhibiting the activity of the Y-box transcription factor ZONAB in cultured epithelial cells. We investigated the role of this TJ-associated signalling pathway in the retinal pigment epithelium (RPE) in vivo by lentivirally-mediated overexpression of ZONAB, and knockdown of its cellular inhibitor ZO-1. Both overexpression of ZONAB or knockdown of ZO-1 resulted in increased RPE proliferation, and induced ultrastructural changes of an epithelial-