抗菌药物配伍简介（Brief introduction of compatibility of antibacterial drugs）.docVIP

抗菌药物配伍简介（Brief introduction of compatibility of antibacterial drugs） Brief introduction of compatibility of antibacterial drugs The antibiotics reasonable compatibility, can achieve synergy or additive effects, which can improve the curative effect; incompatibility could make antagonism, interaction between drug efficacy of offset, decline, and even cause adverse reaction. In combination with antibiotics, we should master indications, pay attention to the pertinence of various varieties, and strive for synergy and avoid antagonism. The compatibility of commonly used drugs is as follows: 1, beta lactams (penicillins, cephalosporins) Beta lactam and beta lactamase inhibitors such as clavulanic acid (acid), Shubatan (tazobactan), tazobactam combined with protective enzyme inhibition and good synergistic effect (beta lactamase inhibitors and beta lactamase binding to the beta lactam damage weakening). For example, clavulanic acid and sulbactam are often combined with ampicillin or amoxicillin to be used in veterinary clinics to treat infections of the digestive tract, respiratory tract or urinary tract in livestock and poultry. Penicillin and probenecid has the synergism (probenecid and penicillin and penicillin inhibited the secretion of competition glomerular excretion, the blood concentration of penicillin). Penicillin was synergistic with aminoglycoside (penicillin destroy bacterial cell wall, is conducive to aminoglycoside drugs enter the bacteria play a role), but the dose should be basically balanced, large dose of penicillin G or other half all penicillin may decrease activity of aminoglycosides. The combined use of penicillin G and oxacillin with TMP has a good synergistic effect. Combined antibiotic penicillin and tetracycline, chloramphenicol, sulfonamides, macrolides, etc. (penicillin for fast acting fungicide, tetracycline as antibacterial agents, interfere with the role of penicillin combined). The exception is that the treatment of meningitis, because pen