最新常用复苏药物和方法的临床应用评（Clinical evaluation of the latest commonly used resuscitation drugs and methods）.docVIP

最新常用复苏药物和方法的临床应用评（Clinical evaluation of the latest commonly used resuscitation drugs and methods） Clinical evaluation of the most commonly used resuscitation drugs and methods (Reprint) From the July 2005 issue of the thirtieth edition of the Chinese Medical Journal of the Liberation Army (7): Http:///cgi-bin/forum... O=6424type=icu Clinical evaluation of commonly used resuscitation drugs and methods 1. resuscitation of vasoactive drugs 1.1 epinephrine, although epinephrine has been widely used in cardiopulmonary resuscitation, there is only a small amount of evidence that it has beneficial effects on patients. In 1992 the American Heart Association (AHA) cardiopulmonary resuscitation guidelines recommend the first intravenous injection of adrenaline standard dose of LMG, and put forward two application of epinephrine at intervals of 3~5min, such as LMG epinephrine is invalid, can be a large dose of adrenaline, gradually increase the dose (1, 3, 5mg), the direct use of the medium dose (5mg each time. Instead of LMG), can also increase the dose according to body weight (O.1mg / kg). High dose epinephrine can increase coronary blood flow during cardiopulmonary resuscitation, enhancement of vascular tone to promote the restoration of spontaneous circulation; unfavorable factors can increase the occurrence of myocardial dysfunction, and recovery in the late occasionally may also lead to high adrenaline state. However, 8 randomized clinical trials (more than 9000 patients with cardiac arrest were included in the trial) showed that there was no significant difference between the initial high-dose group and the standard dose group in terms of discharge, survival, and neurologic recovery. There is no definite conclusion on the need for high-dose epinephrine therapy. 1.2 vasopressin vasopressin is peripheral vasoconstrictor drugs a kind of non adrenergic, play a role in smooth muscle by direct stimulation of V1 receptor and its half-life was 10~20min, compared with the long