2型糖尿病及幽门螺杆菌感染.doc

2型糖尿病及幽门螺杆菌感染 　 作者：孙光喜，谭悦菊，祝永丽 【摘要】 目的：探讨2型糖尿病与幽门螺杆菌（Hp）感染的关系。方法：采用14C呼气试验测定230例2型糖尿病患者Hp感染情况。结果：2型糖尿病患者的Hp阳性率为76%;且消化道症状如烧心、反酸、腹胀等的发生率明显高于Hp阴性组;其中有胃轻瘫者Hp感染率明显高于无胃轻瘫者;Hp阳性组糖尿病症状、糖尿病肾病、糖尿病周围神经病变发生率与Hp阴性组差异无显著性。结论：2型糖尿病患者Hp感染率高于正常人，合并有胃轻瘫者Hp感染率明显高于无胃轻瘫者 ,伴Hp感染的2型糖尿病患者消化道症状较明显,但对糖尿病症状及并发症发生无影响。 【关键词】 糖尿病；幽门螺杆菌；感染 　　The Relationship between Type 2 Diabites Mellitus and H Pilary Infection 　 Abstract: Objective Sdudy the H pilary （Hp）infection in type 2 diabetic patients and the effect of Hp infection on diabites mellitus。Methods 14 C urea brearh test was performed to check the Hp infection in 230 cases of patients suffering from type 2 diabetes mellitus. Results Hp positive rate revealed to be 76% in type 2 diabetic patients. The occurring of gastraenteriz symptoms such as hearburn，regurgitaton and flatulence is significantly higher in Hp positive group than in Hp negative group. The Hp in fection rate has a significant increace in patients with gastroparesis compered to those with no gastroparesis. The two groups have no obvious difference in happening of diabetic symptoms. Diabetiz nephropathy and diabetic peripheral neuropathy. Conclusion Hp infection rate is higher in type 2 diabetic group than in healthy group. Type 2 diabetic patients with gastroparesis has a higher Hp infection rate than these without type 2 diabetic patients with Hp infection have quite obvious gastric symptoms，but Hp infection has no effect on symptoms or complications of diabetes. Key words: Diabetes; H pilary; Infection 为了解2型糖尿病患者幽门螺杆菌(Hp)感染情况，感染后消化道症状，合并胃轻瘫时Hp感染率及感染Hp与2型糖尿病症状、并发症的关系，我们对230例2型糖尿病患者进行了初步研究及探讨。 　　1 资料与方法 　　1.1 一般资料 　　所有病例均为我院内分泌科住院病例，并按1999年WHO提出的新糖尿病诊断标准确诊的230例2型糖尿病患者。糖尿病胃轻瘫的诊断标准：患者有早饱、腹胀、嗳气、食欲不振、烧心、恶心、呕吐等临床表现。糖尿病肾病的诊断依据:尿白蛋白排泄率gt;20 μg/min。糖尿病周围神经病变的诊断依据：肌电图提示神经传导速度减慢者诊断为糖尿病周围神经病变。所有病例检测前未施行抗 Hp治疗。男127例，女103例，年龄35岁～85岁，平均年龄52岁。病史1 a~32 a，平均病史7.6 a。对照组为同期住院患者150例，一般资料对比差异无显著性。 　　1.2 方法 　　测定方法：Hp检测采用14C呼气试验，设备及14C尿素胶囊由安徽养和医疗器械设备有限公司提供。 　　1.3 统计学处理 　　采用χ2检验。 　　2 结果 230例2型糖尿