Ezrin及Moesin在胃癌中表达及其临床意义.docVIP

Ezrin及Moesin在胃癌中表达及其临床意义 　 作者：李莹杰，陶晓峰，贺岩，付红 【摘要】 ［目的］ 探讨Ezrin、Moesin在胃癌组织中的表达情况及其与临床病理参数之间的关系。 ［方法］ 采用免疫组化法检测50例胃癌组织、25例胃黏膜不典型增生和25例正常胃黏膜中Ezrin、Moesin的表达。 ［结果］ ①Ezrin在正常胃黏膜、不典型增生和胃癌中的阳性表达率分别为28.0%、36.0%和86.0%。Moesin在正常胃黏膜、不典型增生和胃癌中的阳性表达率分别为12.0%、24.0%和78.0%。②Ezrin的表达程度与胃癌的临床分期、淋巴结转移有关(Plt;0.01)，与胃癌的分化程度无关(Pgt;0.05)。Moesin的表达程度与胃癌的临床分期、淋巴结转移和分化程度有关(Plt;0.01)。③Ezrin和Moesin的表达之间呈正相关(Plt;0.01)。［结论］ Ezrin、Moesin在胃癌中的高表达与胃癌的临床分期和淋巴结转移有关，两者的联合检测可能成为预测胃癌转移及预后的重要指标。 【关键词】 胃肿瘤 Expression of Ezrin, Moesin in the Gastric Carcinoma and Its Clinical Significance Abstract: ［Purpose］ To explore the expression of Ezrin and Moesin and its correlation to clinico-pathological profile in gastric carcinoma. ［Methods］ The expression of Ezrin and Moesin in 50 specimens of gastric carcinoma, 25 specimens of gastric epithelial dysplasia and 25 specimens of normal gastric tissues were detected by immunohistochemistry. ［Results］ ①The positive expression rates of Ezrin in normal gastric tissues, gastric epithelial dysplasia and gastric carcinoma were 28.0%, 36.0% and 86.0% and those were 12.0%, 24.0% and 78.0% respetively. ②The expression of Ezrin was correlated to clinical stage, lymph node metastasis(Plt;0.01), but not to differentiation(Pgt;0.05), the expression of Moesin was correlated to clinical stage, lymph node metastasis and differentiation(Plt;0.01). ③ The expression of Ezrin was positively correlated to that of Moesin in gastric carcinoma(Plt;0.01). ［Conclusions］ High expression of Ezrin and Moesin is correlated with the clinical stage and lymph node metastasis in gastric carcinoma, combined both detection might be important marker for forecasting metastasis and prognosis in gastric carcinoma examining Ezrin and Moesin. Key words: gastric neoplasms; Ezrin; Moesin; immunochemistry 近年来的研究发现，作为ERM家族成员的Ezrin（埃兹蛋白）、Moesin（膜突蛋白）可以通过对肿瘤细胞黏附分子的调节对恶性肿瘤的侵袭和转移发挥重要作用。目前，国内对这方面的研究报道很少。本研究旨在探讨胃癌中Ezrin、Moesin的表达情况及其与胃癌进展、转移的关系，为胃癌的诊断、预后判断和临床治疗提供新依据。 1 材料与方法 1.1 标本来源 病例资料取自哈尔滨医科大学第二临床医学院2003