健脾清化方治疗脾虚湿热型慢性肾衰临床观察.docVIP

健脾清化方治疗脾虚湿热型慢性肾衰临床观察 　【关键词】 健脾清化方 ［摘要］ 目的：观察健脾清化方治疗脾虚湿热型慢性肾功能衰竭患者的临床疗效及作用机制。方法：将脾虚湿热型慢性肾功能衰竭患者随机分为两组，对照组与健脾清化方组各53例。对照组予以纠正水、电解质紊乱，现代营养及血管紧张素转换酶或受体抑制剂等治疗；健脾清化方组在对照组治疗的基础上加用健脾清化方治疗。结果：健脾清化方组患者的临床症状有明显改善，血肌酐、尿素氮、甘油三酯和低密度脂蛋白均有下降，而红细胞总花环有显著增加，与对照组比较，有统计学意义（Plt;0.05）。结论：早、中期慢性肾功能衰竭患者在常规治疗的基础上加用健脾清化方，能显著降低血脂，提高细胞免疫功能，从而改善肾功能，降低蛋白尿。 　　［关键词］ 健脾清化方; 脾虚湿热; 肾功能衰竭，慢性 　　Clinical study of chronic renal failure with syndrome of dampnessheat due to spleen deficiency treated with Jianpi Qinghua Recipe 　　HE LiQun, CAI Gan 　　(Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China; Department of Digestion, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China) 　　ABSTRACT Objective: To evaluate the effects of Jianpi Qinghua Recipe (JPQHR) on chronic renal failure with syndrome of dampnessheat due to spleen deficiency and its mechanism. Methods: One hundred and six patients were randomly divided into two groups: control group (53 patients treated with routine therapy) and JPQHRtreated group (53 patients treated with routine therapy and JPQHR). Results: Routine therapy combined with JPQHR could improve symptoms. The serum creatinine, blood urea nitrogen, triglyceride and low density lipoprotein decreased significantly in the JPQHRtreated group as compared with those in the control group (Plt;0.05), while the number of erythrocyte rosetteforming cells increased significantly in the JPQHRtreated group as compared with those in the control group (Plt;0.05). Conclusion: Routine therapy combined with JPQHR can significantly decrease blood lipid level and strengthen cellular immune system, so it can lower the urine protein in the early and middle stages of chronic renal failure and improve renal function. 　　KEY WORDS Jianpi Qinghua Recipe; syndrome of dampnessheat due to spleen deficiency; kidney failure, chronic 　　慢性肾功能衰竭(chronic renal failure, CRF)是指原发性或继发性肾脏疾患造成肾结构和肾功能损害，引起一系列代谢紊乱和临床症