复方丹参滴丸及黄芪精口服液联合抗心绞痛疗效及耐药性探究.docVIP

复方丹参滴丸及黄芪精口服液联合抗心绞痛疗效及耐药性探究 　 作者：曹昕阳 付红霞 王永平 【关键词】 复方 摘要：目的：观察和研究复方丹参滴丸和黄芪精口服液联用抗心绞痛作用及有无耐药性存在。方法：按入选标准将我院40例冠心病稳定型心绞痛患者随机分为治疗组和对照组各20例。经双盲方式给药观察8周，治疗组口服复方丹参滴丸及黄芪精口服液。对照组口服单硝酸异山梨酯缓释片,疗程8周。结果：疗程4周后，治疗组心绞痛有效率和心电图有效率明显优于对照组，（Plt;0.05或Plt;0.01），且在疗程6周后无显著降低，而对照组疗程6周后显著降低。结论：长期服用复方丹参滴丸和黄芪精口服液抗心绞痛作用优于单硝酸异山梨酯缓释片，长期服用疗效稳定，不易产生耐药性。 关键词：复方丹参滴丸；黄芪精口服液；抗心绞痛作用；耐药性；心绞痛 Observation and Investigate the Antianginal Effect and Resistance with Polypharmacy of Red Sage Root Drop Pill and Milkvetch Root Oral Liquids Abstract： Objective： To observe and investigate the antianginal effects and resistance with polypharmacy of red sage root drop pill and milkvetch root oral liquids. Methods： 40 patients with stable angina were divided randomly into two groups; 20 were in the treatment group with polypharmacy of red sage root drop pill and milkvetch root oral liquids for 8 weeks; 20 were in the control group with Isosorbide Mononitrate Sustained Release Tablets, 10mg each day for 8 weeks. Result： After 4 weeks,the ECG effective rate and angina effective rate were increased significantly in the treatment group as compared with those in the control group, and these effective rates were not decreased greatly after 6 weeks,while in the control group these rates were decreased obviously.Conclusion： In the long term, the antiangina effects of polypharmacy of red sage root drop pill and milkvetch root oral liquids were better than that of Isosorbide Mononitrate Sustained Release Tablets, and it is hard to produce the resistance. Key words：Red sage yoot drop pill；Milkvetch root oral liquids；Antianginal effect；Resistance；Angina 硝酸酯类药物是经典抗心绞痛药物，但长期服用易产生耐药性［1］，因而限制其临床应用。复方丹参滴丸为我国中成药改良剂型，临床应用已证实可用于心绞痛治疗，具有速效，安全特点［2，3］。黄芪的现代制剂对治疗心绞痛亦有确切疗效［4，5］，但有关两者抗心绞痛长期疗效及抗心绞痛耐药性研究报道较少，由于有无耐药性存在对抗心绞痛药物具有重要的临床意义，本研究拟对这两种药物长期使用抗心绞痛作用及耐药性进行研究，并与单硝酸异山梨酯缓释片比较。 1资料与方法 1.1研究对象：40例患者均为2004年4月至2005年2月我院住院患者其临床症状、心电图表现符合WHO制定的冠心病稳定型绞痛诊断标准，年龄40～70岁，病程三个月以上。心绞痛发作每周五次以上，踏车运动实验阳性，经休息或舌下含服硝酸甘油可缓解症状。其中男23例，女17例。年龄（52.4＋7.3）岁，平均