子宫内膜异位症术后应用异位宁及丹那唑临床观察.docVIP

子宫内膜异位症术后应用异位宁及丹那唑临床观察 　 作者：杨东霞，丛慧芳，曲凡，姚知行 【摘要】 　　目的观察子宫内膜异位症术后应用异位宁与丹那唑的疗效及副反应。方法选择Ⅲ期子宫内膜异位症术后患者60例，随机分为3组。异位宁组于术后第7天口服异位宁2次/d，200 ml/次；丹那唑组于术后第7天口服,2～3次/d,200 mg/次,疗程均为6个月,随访6～30个月。对照组术后两种药均不用。结果异位宁、丹那唑组复发率分别为4.0%和4.5%低于未用药组的30.7%(Plt;0.05), 异位宁与丹那唑组复发率无显著性差异(Pgt;0.05), 异位宁副反应率8%明显低于丹那唑组22.7%(Plt;0.05)。结论异位宁于预防子宫内膜异位症术后复发与丹那唑的疗效相似,但副反应少，易于广泛应用。 【关键词】 子宫内膜异位症 异位宁 丹那唑 　　Abstract：ObjectiveTo observe the clinical efficacy and side-effects of YiWeiNing and Danazol on treatment of patients with endometriosis (stage Ⅲ) after laparotomy. Methods60 cases of endometriosis (stage Ⅲ) after laparotomy were randomly divided into 3 groups: YiWeiNing group was administered YiWeiNing 200ml, Bid, from the 7th day after laparotomy；Danazol group which was administered 200mg of Danazol, Bid~Tid, from the 7th day after laparotomy, for 6 months and was followed up for 6-30 months; Control group wasn’t administered the two medicines. ResultsThe recurrent rats of YiWeiNing group, Danazol group and control group were 4%, 4.5% and 30.9%. There was not statistic significance between YiWeiNing group and Danazol group (Pgt;0.05). There was statistic significance between the treatment group and control group (Plt;0.05). The side-effect rate of YiWeiNing group and Danazol group were 8% and 22.7%. The differences in the groups had statistic significance. ConclusionYiWeiNing was similar to Danazol in the therapeutic effects to prevent postoperation recurrence, but YiWeiNing has few side-effects and was widely applied in clinical treatment. 　　Key words：Endometriosis； YiWeiNing ； Danazol 　　子宫内膜异位症(以下简称内异症)已成为妇科常见病,重症以手术治疗为主,但术后易复发,近年来有报道认为丹那唑对内异症有较好的疗效。本文对我院行保守(保留生育功能)或半保守(保留卵巢功能)手术的III期内异症患者术后应用异位宁和丹那唑疗效进行了观察。现介绍如下。 　　1 资料与方法 　　1.1 一般资料 　　回顾分析了我院200303～200510间行保守或半保守手术并经病理证实为盆腔子宫内膜异位症(包括卵巢内异囊肿),美国生殖学会修订的分类标准（γ-AFS）分期为Ⅲ期以上［1］,患者52例, 年龄24～39岁,平均年龄32岁,均已婚。52例中40例有人流史,10例无人流等宫腔操作史,6例为不孕症患者;术前均有不同程度的痛经、月经过多、下腹痛或腰骶部疼痛、性交痛。其中术后应用异位宁20例, 丹那唑19例,未用药组13例。所有病例均无高血压病、心脏病、糖尿病病史,术前半年无服用激素类药物史,血常规、尿常规及肝肾功能均正常