尼莫地平及银杏叶注射剂合用治疗急性脑梗死临床观察.docVIP

尼莫地平及银杏叶注射剂合用治疗急性脑梗死临床观察 　【摘要】 目的 探讨尼莫地平与银杏叶注射剂合用治疗急性脑梗死的临床疗效。方法 将89例急性脑梗死病人随机分成尼莫地平组（29例，只用尼莫地平），银杏叶组（30例，单用银杏叶注射剂）及两药合用组（30例）。尼莫地平的用法为尼莫地平口服，每次30mg，每日3次。银杏叶注射剂的用法为20ml加入到5%葡萄糖氯化钠溶液或0.9%氯化钠溶液250ml中静脉滴注；每日1次。3组均治疗30天。其他治疗两组相同。治疗前后分别进行神经功能缺损评分。检查血常规、肝功能、肾功能、凝血功能。结果 两组合用显效率66.67%，有效率93.33%，均显著高于尼莫地平组和银杏叶组（Plt;0.01），未发现有严重的肝、肾功能损害及出血不良反应。结论 尼莫地平与银杏叶注射剂合用治疗急性脑梗死安全有效，疗效优于其中一种药物者。 【关键词】 尼莫地平；银杏叶注射剂；脑梗死；治疗效果；不良反应 Effect of nimodipine combined with YinXingYe on the treatment of acute cerebral infarction 【Abstract】 Objective To evaluate the clinical efficacy of YinXingYe combined with nimodipine on the treatment of acute cerebral infarction. Methods Eighty nine patients were randomly divided into three groups:Twenty nine patients were treated with nimodipine 30mg po tid,thirty patients were treated only with 20ml YinXingYe once daily by intravenous drip.Thirty patents were treated with YinXingYe and nimodipine.Three groups were treated for 30days.Impaired neurological function score,blood routine,liver and kidney function,blood coagulation were examined before and after treatment. Results Significant effective rate and effective rate were 66.67% and 93.33% respectively in those patients treated with YinXingYe combined with nimodipine,significantly higher than that in the other two guoups (Plt;0.05).No severe adverse reactions after treatment were found. Conclusion YinXingYe combined with nimodipine is an effeetive and safe regimen for the treatment of acut cerebral infarction. 【Key words】 YinXingYe injection solution;nimodipine;cerebral infarction; treatment outcome;adverse reaction 尼莫地平为钙离子拮抗剂，银杏叶注射剂为一中药制剂，有抗凝、保护脑细胞的作用。为探讨两药联用的临床疗效，将89例急性脑梗死病人随机分成银杏叶组、尼莫地平组和两药合用组。并比较3组的临床疗效及不良反应。 1 资料与方法 1.1 一般资料 1.1.1 入选标准 89例入选病人均为我院内科2002年3月～2006年7月的住院病人。符合1995年全国第四届脑血管病学术会议制定的脑血管病诊断标准［1］，均经头颅CT检查而确诊。均为首次发病，病程2～48h。患者均无昏迷，并排除以下情况： （1）出血性脑梗死；（2）有严重的心、脑、肾、肺等疾 病者；（3）有出血倾向或凝血功能差者。 1.1.2 分组 将病人随机分为3组。两药合用组30例，男21例，女9例；年龄45～75岁，中位年龄65岁；病程2～48h，中位时间22h；其中基底节区梗死19例，脑叶梗死8例，小脑梗死2例；伴高血压23例