用谷峰比值及平滑指数评价海捷亚降压作用探究.docVIP

用谷峰比值及平滑指数评价海捷亚降压作用探究 　【摘要】 目的：评价海捷亚对轻、中度原发性高血压患者降压作用的稳定性。方法：选取2006年1月至2006年10月我院门诊或住院患者中轻、中度原发性高血压患者40例，每日口服海捷亚1片，平均疗程8周（包括安慰剂洗脱期2周），于服药前及服药8周后进行动态血压监测并计算谷峰比值与平滑指数。结果：治疗8周后：①与服药前比较平均收缩压和平均舒张压分别下降17.9mmHg和12.7mmHg，脉压差明显减少，差异具有显著性(P＜0.05)；②用药后收缩压、舒张压谷峰比值分别为76.7%和71.2%；③平滑指数为SBP1.14±0.39，DBP 1.09±0.27。结论：海捷亚对轻、中度原发性高血压具有平稳的降压作用。 【关键词】 海捷亚； 谷峰比值； 平滑指数 　　Evaluating Antihypertensive Efficacy of Hyzaar for Essential Hypertention Through the T/P Ratio and Smoothness Index 　　　Abstract： Objective： To evaluate the smooth control effect of Hyzaar in patients who sufferred from mild-moderate essential hypertention. Method： 40 patients out of outpatients or inpatients with mild-moderate essential hypertention from Jan. 2006 to Oct. 2006 were included in this study. All cases were given Hyzaar 1 table once a day for 8 weeks (including placebo elution for 2 weeks). A 24-hour ambulatory blood pressure monitoring was performed, respectively at pre-treatment and after 8-week treatment. Moreover, T/P ratio and smoothness index were tested. Result： After 8-week administration, firstly, the mean systolic and diastolic blood pressure decreased 17.9 and 12.7mmHg respectively. The pulse pressure also dropped significantly. Secondly, the T/P ratio of systolic blood pressure was 76.7%, the diastolic blood pressure was 71.2%. Thirdly, the smoothness index of systolic blood pressure was 1.14 ± 0.39, the diastolic blood pressure was 1.09±0.27. Conclusion： Hyzaar has smoothly control effect on the patients with mild-moderate essential hypertention. 　　Key words： Hyzaar; T/P ratio; Smoothness index 　　原发性高血压是动脉粥样硬化心脑血管疾病的重要危险因素，研究证实有效的抗高血压治疗是预防心脑血管疾病的主要措施，目前动态血压监测已广泛应用于高血压临床诊断、疗效评价和预后判断［1］。海捷亚是血管紧张素II受体（ATII型）拮抗剂（氯沙坦钾）和利尿剂（氢氯噻嗪）的复方制剂。本研究以动态血压监测（ABPM），并计算谷峰比值和平滑指数评价海捷亚对轻、中度原发性高血压的降压作用。 　　1 资料和方法 　　1.1 病例选择条件：入选病例需符合下列条件: ①按1999年WHO标准确诊为原发性高血压(SBP 140～180 mmHg ,DBP 90～110mmHg)。②接受治疗的患者必须是其他单一种药物降压无明显效果者。③对海捷亚产品中任何成分过敏者, 磺胺类药物过敏者, 肝、肾功能异常者除外。④全部入选患者入选前除血压波动外其他病情稳定。入选前检查血糖、血脂、肝肾功能、电解质、心电图、心脏彩超等。 　　1.2