环境响应型高分子凝胶在智能给药系统中医学应用及进展.docVIP

环境响应型高分子凝胶在给药系统中应用 柳森 （天津大学化工学院，天津 300072） 摘要：智能药物是由智能高分子载体构成的具有自我反馈功能的给药系统,这种智能性主要表现在智能高分子载体上,而所谓的智能高分子载体材料是指通过系统协调材料内部的各种功能,对环境可感知且可响应,并且具有功能发现能力的一种新材料。智能高分子材料中研究最广泛的为环境响应性高分子凝胶,它能对周围的环境刺激因素,如温度、pH、离子、电场、磁场、溶剂、反应物、光或应力等做出有效响应并且自身性质也随之发生变化,即发生膨胀与收缩,这种膨胀有时能达到几十倍乃至几千倍。由于环境响应高分子凝胶的独特响应性,在化学化工、生物医学、药物载体等方面具有很好的应用前景。Environmental response type polymer gel in the application of drug delivery system Liu Sen (School of Chemical Engineering , Tianjin University , Tianjin 300072,China) Abstract: intelligent drug is by intelligent high polymer carrier with a self feedback function of the drug delivery system, this kind of intelligent mainly displays in intelligent high polymer carrier, and the so-called intelligent high polymer carrier material is through the system coordination material internal various kinds of functions, on the environment can be perceived and response, and has the ability of function found a kind of new material. Intelligent high polymer materials research in the most widely for environmental response sex polymer gel, it can on the surrounding environment stimulation factors, such as temperature, pH, ion, electric field, magnetic field, solvent, reactant, light or stress, etc to make effective response and own properties changes, namely happen expansion and contraction, this kind of expansion sometimes can achieve a few times and even thousands of times. Due to the environmental response polymer gel unique response sex, in chemistry and chemical engineering, biological medicine, drug carrier etc, it has good application prospect. Keywords: intelligent drug, intelligent high polymer, environmental response type, medicine 前言： 1991年，法国物理学家德热纳在其诺贝尔授奖会上首次提出“软物质”这一概念，自此，软物质引起全世界的广泛关注。软物质是指处于固体和理想流体之间的复杂态物质。它一般由大分子或基团组成，在自然界中广泛存在，如液晶、聚合物、胶体、膜、泡沫、颗粒物质、生命体系等[1]。 软物质影响着我们的生产生活，与人们的生活休戚相关，如我们使用的橡胶轮胎、墨水、洗涤剂、化妆品以及药品等，而我们生物体也基本是由软物质如细胞、体液、蛋白质、DNA等组成[2]。因此，对软物质的深入研究，对生命科学、化学化工、医学、药品、食品、材料、环境、工程等有着重要的意义。 本文将主要介绍环境响应型高分子凝胶作为药物载体在智能化给药系统中的应用和医学进展。 1，环境响应型高分子凝胶作为药物载体在智能化给药系