阿昔洛韦片（acyclovir tablets）.docVIP

阿昔洛韦片（acyclovir tablets） Aciclovir Tablets (Aciclovir Tablets) (no cGMP tablets, ACV tablets) This product is mainly composed of A Silowe. [traits] This product is white. [pharmacology and toxicology] Antiviral agents. It has inhibitory effects on herpes simplex virus, varicella zoster virus and giant cell virus in vitro. This product into the herpes virus infected cells, and deoxyriboside competition virus thymidine kinase or cellular kinases phosphorylate activated by drugs, acyclovir three phosphate, and then through two ways: the inhibition of virus replication interference virus DNA polymerase, inhibits the replication of virus; DNA polymerase II in the role, combined with the growth of DNA chain extension of DNA chain disruptions caused by. This product has a special affinity for viruses, but it has low cytotoxicity to mammalian host cells. In vitro cell transformation assay is carcinogenic, but there is no evidence of carcinogenicity in animal studies. Some animal studies have shown that high levels of drugs can cause mutations, but there is no evidence for chromosomal changes. The carcinogenic and mutagenic effects of this product are not clear. A large dose of injection may cause atrophy of the testis and decrease in sperm count. The drug can pass through the placenta, and animal experiments have shown no effect on the embryo. [pharmacokinetics] Oral absorption is poor, about 15% to 30% absorbed by the gastrointestinal tract. The influence of food intake on serum concentration is not obvious. It can be widely distributed in tissues and body fluids, including brain, kidney, lung, liver, small intestine, muscle, spleen, milk, uterus, vagina, mucous membrane and secretions, cerebrospinal fluid and herpes fluid. In the kidney, liver, and small intestine, the concentration is high, and the concentration in the cerebrospinal fluid is about half of the concentration in the blood. Drugs can pass through the placenta. 200mg and 400mg were taken every 4 hours, and th