细胞视黄酸结合蛋白与肿瘤相关研究.pdf（Study on the relationship between retinoic acid binding protein and tumor.Pdf）.docVIP

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细胞视黄酸结合蛋白与肿瘤相关研究.pdf（Study on the relationship between retinoic acid binding protein and tumor.Pdf）.doc

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细胞视黄酸结合蛋白与肿瘤相关研究.pdf（Study on the relationship between retinoic acid binding protein and tumor.Pdf）

细胞视黄酸结合蛋白与肿瘤相关研究.pdf（Study on the relationship between retinoic acid binding protein and tumor.Pdf） 68 The chemistry of life, 2011, Volume 1, 31 By Mini Review CHEMISTRY OF LIFE 2011, 31 (1) Article number: 1000-1336 (2011) 01-0068-04 Study on the relationship between retinoic acid binding protein and tumor Yang Fang College of Agronomy and life science, Ankang University, Ankang 725000, China Abstract: the cellular retinoic acid binding protein (CRABP) interaction between cytoplasm and nucleus as retinoic acid mediated the retinoic acid nuclear receptors, while promoting retinoic acid The activity of metabolic enzymes enhanced the transformation rate of retinoic acid. In vertebrate cells, CRABP contains two highly homologous proteins: CRABP1 and CRABP2. CRABP belongs to low molecular weight proteins and is highly conserved among species. Existing studies show that CRABP gene abnormalities are present in many tumors The level of gene expression is different from that of normal tissue. The aberrant methylation of CRABP gene is associated with low survival rate in some patients with tumor, CRABP base It can become a common molecular target for tumor diagnosis and prognosis. Keywords: retinoic acid binding protein; methylation; tumor; molecular target CLC number: Q75 Retinoic acid (retinoic, acid, RA) is vitamin A (retinol) Derivatives are important ligands for members of the nuclear receptor family, and are present The most important of the differentiation agents found in various tissues, Cells are highly inductive and are widely used in tumors Chemotherapy. Because the chemical properties of retinoic acid are not stable enough, they are fat Solubility, therefore, must be in the process of its absorption, translocation and secretion A combination of specific proteins. Its physiological function mainly consists of two kinds of proteins The receptors are retinoic acid receptor and retinoic acid binding protein. Retinoic Acid receptors (retinoic, acid, receptor, RAR) inc