CT引导下微波消融联合吉西他滨与顺铂方案化疗治疗中晚期肺鳞癌临床观察.pdfVIP

中国生化药物杂志 2017 年第8期 总第 37 卷 论著 临床与药物 DOI: 10.3969/j.issn.1005-1678.2017.08.102 CT 引导下微波消融联合吉西他滨与顺铂方案化疗治疗中晚期 肺鳞癌临床观察 陶志刚，周健△ （杭州市肿瘤医院 放射科，浙江 杭州 310000 ） [摘要] 目的 探讨吉西他滨与顺铂化疗方案联合CT引导下微波消融应用于中晚期肺鳞癌治疗的临床疗效。方法 选取2013年3月~2015年 6月76例杭州市肿瘤医院收治的中晚期肺鳞癌患者为研究对象，随机分为治疗组与对照组，各38例。对照组患者给予吉西他滨与顺铂化疗方 案治疗，治疗组患者在对照组的基础上联合CT引导下微波消融治疗，治疗结束后对两组患者的近期疗效进行评价，观察两组患者不良反应 P 发生情况，并进行1~2年的随访。结果 治疗组患者的总有效率显著高于对照组（ ＜0.05 ）；治疗组患者微波消融术后出现气胸2例，咯血3 例，发热2例，在对症处理后恢复。2组因化疗引发的不良反应发生率对比差异无统计学意义；治疗组患者的PFS显著较对照组延长，1年生存 P 率及2年生存率显著高于对照组（ ＜0.05 ）。结论 吉西他滨与顺铂化疗方案联合CT引导下微波消融应用于中晚期肺鳞癌治疗的临床疗效显 著，值得临床推广。 [关键词] 肺鳞癌；中晚期；吉西他滨；顺铂；微波消融 [中图分类号] R734.2 [文献标识码] A CT guided microwave ablation combined with gemcitabine and cisplatin regimen for the treatment of advanced squamous cell carcinoma of the lung TAO Zhi-gang, ZHOU Jian△ (Department of Radiological, Cancer Hospital of Hangzhou City, Hangzhou 310000, China) [Abstract] Objective To investigate the clinical efficacy of gemcitabine and cisplatin chemotherapy combined with CT guided microwave ablation used in treatment of advanced squamous cell lung cancer. Methods 76 patients with lung squamous carcinoma in our hospital from April 2013 to July 2015 were selected,and randomly divided into treatment group and control group,38 cases in each groups. The control group were treated with gemcitabine and cisplatin chemotherapy. The patients in the treatment group in the control group based on the combined CT guided ablation under microwave, after the end of treatment to evaluate the efficacy of the two groups of patients, observe two groups of