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Bioprocess automation ;LV Automatisierung von Bioprozessen;LV Automatisierung von Bioprozessen;Bioprocess(生物加工) automation key elements of the bioprocess contribution(贡献) of automation  to processing;LV Automatisierung von Bioprozessen;;Reasons for increasing need for automation and use of computers in bioprocessing需要自动化和计算机的使用生物敷料的原因Need for accelerated(加速的) process development and increased efficiency and economies of production processes process level过程层 process regimes(体系) became far more complex and sophisticated复杂的高级的 e.g. 例如(batch ? fed batch(流加式操作) continuous increase of variables to be monitored要监视的变量的连续增加 increasing complexity of variables日益复杂的变量 level of quality(质量) management demands (需要) related to quality management increased dramatically显著地增加 (hidden plant, makes approx大约. 35% (up to 70%) of costs成本) increased demands on documentation ;Requirements for automated process operation 自动化工艺操作要求 detailed knowledge of process and individual procedures过程和单个步骤的详细知识 monitoring (availability of sensors传感器的可用性, analytical devices..) ? software ? hardware;Substrate(培养基) tank罐;UPSTREAM PROCESSING上游处理过程;Upstream processing cleaning sterlisation灭菌 filtration(过滤) homogenisation(均化) feed control进料控制 ... ... ... ... documentation;Fermentation process;Fermentation process Main characteristics主要特点 complex复杂的 highly interactive相互影响的 parallel平行的 non linear非线性;BIOPROCESS OPERATION;Downstream-processing cleaning Sterlisation (灭菌,消毒) feed centrifugation离心分离 Homogenisation (均化) filtration过滤 waste management 废物处理 sampling采样 ... ... documentation;Bioprocess automation;Regler ist das Grundelement für die Automatiserung der Proze?führung;LV Automatisierung von Bioprozessen;LV Automatisierung von Bioprozessen;LV Automatisierung von Bioprozessen;LV Automatisierung von Bioprozessen;Reasons for an increasing need for automation and use of computers in bioprocessing 越来越需要自动化和计算机的使用生物工艺的原因 process level process regimes(体系) became