联用尼美舒利对5—氟尿嘧啶在大鼠体内药代动力学地影响.pdfVIP

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  • 2017-10-03 发布于江苏
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联用尼美舒利对5—氟尿嘧啶在大鼠体内药代动力学地影响.pdf

administered5一Fuwithat5 bloodwascollectedinto ip day.Carotid tubesbeforeand minafter heparinized at1,3,5,10,20,30,60,90,120 5--Fu saltsolution(48 was ip physiological mg·kg一1).Plasmasepara— ted for15min(3000r·min-1).Thewere bycentrifugation specimens storedatref untiltobe rigerator analyzed. 3.Data analysis The werecalculated software pharmacokineticparameters by3p97 the Chinese thecorrelationa— developedby Society.And Pharmacological dosesweredeterminedlinear AUC,C。。and mong by regression. Results of Identificationdeterminationof5一flurouracilin plasma of5——flurouracilandthe Chromatograms specifity Theretentiontimeof5一flurouraciliS(4,0750.008)minandreten— tiontimeof5一BruinternalstandardiS(7.450 en— 0.020)min.Plasma materialshasnointerferencewiththecontentof5--flurouracil. dogenous Standardcurve 5——Fuofvariousknownconcentrationwasaddedto atthefi—. plasma nal of were concentration pro— 40,20,10,5,2.5,1.25/*g·mL~.They cessed tothe linear wascon— above according

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