基因组定向编辑技术的专利概述及其对高校创新创业教育的启示-遗传.PDFVIP

Hereditas (Beijing) 2015 年 12 月, 37(12): 1258―1262 遗传学教学 基因组定向编辑技术的专利概述及其对高校创新创业 教育的启示 1, 2 1 3 1 樊祥宇 ，林燕萍 ，廖国建 ，谢建平 1. 西南大学生命科学学院，三峡库区生态环境与生物资源省部共建国家重点实验室培育基地，三峡库区生态环境教育部重点 实验室，现代生物医药研究所，重庆北碚 400715 2. 济南大学生物科学与技术学院，济南 250022 3. 西南大学药学院，现代生物医药研究所，重庆北碚 400715 摘要:锌指核酸酶(Zinc finger nucleases ，ZFN) 、转录激活子样效应因子核酸酶(Transcription activator-like effector nucleases ，TALEN)和成簇规律间隔短回文重复序列(Clustered regularly interspaced short palindromic repeats ，CRISPR)/Cas9 核酸酶是三个主要的基因组定向编辑技术。它们在基因功能研究、物种改造和疾病预防 与基因治疗等各个领域都有重大科学研究及应用价值。每个技术背后都有过和有着激烈的知识产权归属之争。 本文归纳总结这三大基因组定向编辑技术的知识产权，以期为研发具有自主知识产权的基因组编辑工具提供一 些借鉴，也为现阶段高校创新创业教育提供启示。 关键词:ZFN ；TALEN；CRISPR/Cas；知识产权 Overview of patents on targeted genome editing technologies and their implications for innovation and entrepreneurship education in universities 1, 2 1 3 1 Xiangyu Fan , Yanping Lin , Guojian Liao , Jianping Xie 1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco -Environment and Bio -Resource of the Three Gorges Area, Key Laboratory of Eco-environments in the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei 400715, China; 2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China; 3. Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Beibei 400715, China Abstract: Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great signi- ficance in scientific research and applications on aspects of functional genomics research , species improvement