多囊卵巢综合征-第三军医大学学报.DOCVIP

应用来曲唑对多囊卵巢综合征患者促排卵治疗 胡敏 丘彦 （重庆医科大学附属第一医院辅助生殖中心，重庆，400016） 【摘要】目的：探讨来曲唑(1etrozole，LE)用于多囊卵巢综合征患者的促排卵疗效。方法：将189例(共367个月经周期）多囊卵巢综合征患者分别用来曲唑(68例)及枸橼酸克罗米芬 (96例)促排卵治疗。监测两组治疗前后卵泡生长率、血清激素，子宫内膜生长、宫颈黏液性状变化情况。结果：卵泡生长速率LE组与CC组分别为1.67mm/d、1.78mm/d(P=0.14)。T水平LH峰日LE组与CC组分别为2.1±1.9 ng/dl，2.0±1.7ng/dl (P=0.93)，LE组T水平LH峰日与月经第3天分别为2.1±1.9 ng/dl，1.4±1.5 ng/dl (P=0.09)。E2水平LH峰日LE组与CC组分别为89.0±59.5pg/ml, 108.1±46.0pg/ml (P=0.13)。子宫内膜厚度LH峰日LE组与CC组分别为11.3±1.6mm,9.7±1.4 mm (P=0.07)，宫颈粘液评分LE组与CC组分别为11.0±1.1，8.3±3.1 (P=0.003)。结论:LE用于多囊卵巢综合征不孕患者诱导排卵有效，治疗未加重雄激素水平异常。 【关键词】来曲唑;促排卵;多囊卵巢综合征;血清雄激素 【中图分类号Objective:To investigate the clinical effect of the therapy of Letrozole (LE) in induction of ovulation in polycystic ovary syndrome(PCOS). Methods: 189 consecutive infertile patients with PCOS were recruited. 68 patients were randomized to the LE group (178 cycles) and the 96 patients were recruited to the Chloramiphene (CC) group (189 cycles). Main outcome measure(s): growth rate of follicles, serum hormone level, endometrial thickness, cervix mucus, ovulation and pregnancy rates. Result(s): The growth rate of follicles in LE group and CC group were 1.67mm/d and1.78mm/d (P=0.14). The level of serum T on the day of LH peak in LE group and CC group were 2.1±1.9 ng/dl，2.0±1.7ng/dl (P=0.93). The LE group’s serum T level in on the day of LH peak and on day 3 were 2.1±1.9 ng/dl，1.4±1.5 ng/dl (P=0.09). The level of serum E2 on the day of LH peak in LE group and CC group were 89.0±59.5pg/ml, 108.1±46.0pg/ml (P=0.13). The endometrial thickness in LE group and CC group were11.3±1.6mm,9.7±1.4 mm (P=0.07) .The cervix mucus in LE group and CC group were11.0±1.1，8.3±3.1 (P=0.003) . Conclusion(s): Letrozole was benefit for ovulation induction in patients with polycystic ovary syndrome, and it didn’t aggravate the level of serum T abnormality. [key words] Letrozole; ovulation-induction; polycystic ovary syndrome(PCOS); serum T枸橼酸克罗米芬(clomiphene citrate，CC)作为治疗排卵障碍的一线药