处方禁忌（Prescription contraindication）.doc

处方禁忌（Prescription contraindication） Incompatibility of commonly used prescription drugs Various drugs act alone on the human body, which can produce their own pharmacological effects. When combined with a variety of drugs, due to their interaction, to enhance efficacy or reduce the side effects, also can make the subpotent or should not have side effects, adverse reactions and may lead to some specific hazards, medication. From the current level, in most cases only two kinds of drug interactions, drug interactions occur more than two or more complex, so here we mainly discuss the two kinds of drugs adverse interactions, often clinically some drugs in combination, so in addition to drug interactions, and can physiological changes of compatibility. The compatibility reactions among commonly used prescription drugs are briefly described as follows. 1, should not be combined with penicillin G drugs 1.1 glucose penicillin G compatibility with Glucose Injection, so that the decomposition of penicillin G accelerated, reducing antibacterial effect, and with the increase in glucose concentration, the decomposition rate of penicillin G accelerated. 1.2 erythromycin penicillin G can inhibit the synthesis of bacterial cell wall peptidoglycan, thereby preventing the growth of bacteria, macrolide erythromycin can promote the cell wall mucopeptide to obtain amino acid, promote the synthesis of cell wall, at the same time, erythromycin is the available antimicrobial agent that inhibits the growth of bacteria, weaken the bactericidal action of penicillin G. 1.3 prednisolone prednisone, ethanol as a solvent, ethanol accelerated the hydrolysis of beta lactam drugs, and penicillin G dissolved together, so that penicillin G hydrolysis, accelerate the reduction in potency. 1.4 other combination of penicillin G and dexamethasone, can appear hypokalemia; combination of Sulfanilamide and sulfonylurea hypoglycemic agents, prone to lowering blood pressure and reaction; and potassium may cause