壳聚糖海藻酸钠（Chitosan alginate）.docVIP

壳聚糖海藻酸钠（Chitosan alginate） Preparation and properties of chitosan sodium alginate Ibuprofen Sustained Release Microspheres Source: Chinese Paper Download Center [08-07-04 11:17:00] author: Wang Jin, Li Zhulai, Chen editor: studa0714 Preparation and properties of chitosan sodium alginate Ibuprofen Sustained Release Microspheres Source: Chinese Paper Download Center [08-07-04 11:17:00] author: Wang Jin, Li Zhulai, Chen editor: studa0714 [Abstract] objective to prepare Ibuprofen Sustained release microspheres using chitosan and sodium alginate as matrix materials. Methods the entrapment efficiency of microspheres was optimized, and the optimum preparation conditions of microspheres were obtained by L16 (45) orthogonal experiment with complex coacervation method. Results the chitosan concentration was 4 mg/mL, the stirring speed was 600 r/min, the reaction temperature was 30 DEG C, the system pH 4.5, and the crosslinking agent glutaraldehyde dosage 1.5 mL was the best process. Ibuprofen Sustained release microspheres were prepared with the best preparation conditions. The size of the microspheres was (31.6 + 1.7) mu m, and the encapsulation efficiency was (64.6 + 2.2)%. Conclusion microsphere has good morphology and stability, and has a good sustained-release effect. [keyword] Bloven; chitosan; microspheres; delayed action preparations; technology, pharmaceutical ABSTRACT: Objective The suitable sustained-release microspheres containing ibuprofen were prepared using chitosan and sodium alginate as base material. Methods The L16 (45) orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microspheres. The complex coacervation method was selected. Results The result show that C (chitosan) =4.0 mg/mL, v=600 r/min. PH=4.5, T=30 C, V (pentanedial) =1.5 mL were the best preparation condition. The average particle size of the microspheres was (31.6 + 1.7) M. The average drug envelopment was (64.6 + 2.2)