第一课：葡萄糖传感器.pdfVIP

Anal. Chem. 2010, 82, 3581–3587 Si:WO3 Sensors for Highly Selective Detection of Acetone for Easy Diagnosis of Diabetes by Breath Analysis Marco Righettoni, Antonio Tricoli, and Sotiris E. Pratsinis* Particle Technology Laboratory, Department of Mechanical and Process Engineering, Institute of Process Engineering, ETH Zurich, CH-8092 Zurich, Switzerland Acetone in the human breath is an important marker for The remaining small fraction consists of more than 1000 volatile noninvasive diagnosis of diabetes. Here, novel chemo- traces with concentrations ranging from parts per trillion (ppt) to resistive detectors have been developed that allow rapid parts per million (ppm)1,9,10 that are either generated in the body measurement of ultralow acetone concentrations (down (endogenous) or absorbed as contaminants from the environment to 20 ppb) with high signal-to-noise ratio in ideal (dry air) (exogenous).11 Some endogenous compounds, including inorganic and realistic (up to 90% RH) conditions. The detector gases (e.g., NO, CO) and volatile organic compounds (VOCs, e.g. films consist of (highly sensitive) pure and Si-doped WO3 ethane, pentane, ammonia, acetone, ethanol), can be assigned to nanoparticles (10-13 nm in diameter) made in the gas specific pathologies and, thus, are utilized as breath markers.1,3 phase and directly deposited onto interdigitated elec- In particular, acetone is a selective breath marker to type-1 trodes. Their sensing properties (selectivity, limit of diabetes.1,12 It is produced by hepatocytes via decarboxylation of detection, response, and recovery times) have been excess acetyl-coenzyme A.4 The acetone