姜黄素衍生物的合成和生物活性研究（英文）.pdfVIP

第34卷第 5期 林 产 化 学 与 工 业 Vo1．34No．5 2014年 10月 ChemistryandIndustry ofForestProducts 0ct．2014 doi：10．3969／j．issn．0253—2417．2014．05．011 SynthesisandBiologicalActivityof urcum l●n D1eriv‘at·iv‘es KUANG Chun—tao，LIXiang—zhou ，XUE Hai—peng， DENG Nan，WANG Ling—zhi (CollegeofMaterialScienceandEngineering，CentralSouthUniversityofForestry andTechnology，Changsha410004，China) KUANG Chnil-tao Abstract：Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification．isomerization．chlorinationandesterification．Theyieldsofeurcuminderivativescl—c4were80．5％ ，83．7％ ， 81．2％ and85．4％ ．respectively．Theirstructureswereconfirmed by IR， H NMR and ”C NMR．Theantioxidative and antibacterialactivitiesoftargetcompoundscl—e4 wereevaluated．TheIC50valuesforscavengingofDPPH ‘were 164．14 ± 0．82．166．98±0．66，171．974-0．99and 175．10-42．34mg／L，respectively．Theirantioxidativeactivitywaslowerthanthatof curcuminf36．22±0．22mg／L)．Thisprovedtheimpo~anceofphenolicOH．Thetargetcompoundscl—c4displayedhigh antibacterialactivity，especiallycompounde4．Theminimalinhibitingconcentration(MIC)ofc4againstStaphylococcusaureus， Escherichiacoli，Penicillium sp．andAspergillus nigerwere0．5，0．5，0．25and1．0g／L，respectively．Thereishopetoobtain antibacterialcandidatesbycureuminmodificationwith ，口一unsaturatedcarbonylcompounds． Keywords：curcuminderivatives；synthesis；antioxidantactivity；antibacterialactivity CLCnumber：TQ35：R914．5 Documentcode：A ArticleID：0253—2417(2014)05—0067—06 姜黄素衍生物的合成和生物活性研究 旷春桃，李湘洲，薛海鹏 ，邓 楠，王玲芝 (中南林业科技大学材料科学与工程学院，湖南 长沙 410004) 摘 要 ：以姜黄素和马来酸酐为原料 ，经酯化、异构化、酰氯化和酯化