儿童肾病综合征相关生长迟缓及防治进展.pdfVIP

·综述· 儿童肾病综合征相关生长迟缓及防治进展 张妙(综述) 高岩(审校) 【摘要】 肾病综合征(nephroticsynome，NS)是儿童常见的肾脏疾病。糖皮质激素(glucocorticoids， hormone，GH)分泌和合成障碍，使GH GC)作为Ns治疗一线用药，可通过多种途径引起生长激素(growth 水平降低从而影响生长发育。肾病本身可干预胰岛素样生长因子及胰岛素样生长因子结合蛋白的分泌和 调节，生长激素．胰岛素样生长因子轴发生变化是Ns患儿生长迟缓的原因之一。Ns患儿骨代谢异常和甲 状腺功能低下也影响其生长发育。该文对Ns相关生长迟缓及其防治作一综述。 【关键词】 肾病综合征；儿童；生长迟缓 基金项目：广州市科技计划项目(201300000168)；广东省人口计生委科研项目(2012263) treatmentof retardationinchildrenwith ofthe and syndrome Progressprevention growth nephrotic WomenandChildren’jMedical Miao．Gao ofPaediatricNeurology，Guangzhou Center， Zhang Yan．Department Medical 510000，China GuangzhouUniversity，Guangzhou acommondiseasein thefirst- 【Abstract】Nephroticsyndrome(NS)is children．Glucocorticoids(Gc)is and disorder various linetreatmentforNSandCancause hormone(GH)secretion ways growth synthesis through whichmduceslevelsof and aleaffected．For disere GH．Consequently，thegrowthdevelopment another，kidney inthesecretionand ofinsulin-like insulin-likefactor canintervene regulation growthfactor(IGF)andgrowth axis’S aroleinchildren’Sretaldation．Other bindingprotein(姗P)．GH．IGFchangeplays growth factors，such focusesonthe as and the inhibition．TIlisreview bonemetabolicdisturbance growth hypothyroidismaggravates inchildrenwithNS． andtreatmentof retardation prevention growth 【Keywords】 Retardation Nephrotic