细胞色素P450特性.docxVIP

细胞色素P450的特性及其研究进展摘要：细胞色素P450是内质网膜上混合功能氧化酶系统的末端氧化酶，在生物体内分布广泛，主要催化机体内源和外源性物质在体内的氧化反应。在临床药物的生物学转化中，它参与大部分药物的生物氧化，因此具有重要的生物学意义。关键词：细胞色素P450 特性机理功能Characteristics ofcytochromeP450 and its research developmentABSTRACT: Being the terminal oxidase component of mixedfunction oxidase system in the membrane of endoplasmic reticulum,cytochrome P450 (CYP450) has been found in all living organisms and can catalyze the oxidation of a variety of endogenous and xenobiotic compounds. This article reviewed the mechanistic explorations on CYP450- catalyzed reactions,especially the recent investigations on the me