β-环糊精与抗组胺类药物络合可降低苦味.pdfVIP

Reduction of Bitterness of Antihistaminic Drugs by Complexation with β-Cyclodextrins NAO ONO,1 YUJI MIYAMOTO,1 TAKAKO ISHIGURO,2 KEIICHI MOTOYAMA,1 FUMITOSHI HIRAYAMA,2 DAISUKE IOHARA,2 HAKARU SEO,2 SATOSHI TSURUTA,2 HIDETOSHI ARIMA,1 KANETO UEKAMA2 1Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan 2 Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, Japan Received 18 April 2010; revised 24 October 2010; accepted 30 October 2010 Published online 28 December 2010 in Wiley Online Library