药物不良反应之皮肤表现探究.pptVIP

* Erythema Multiforme, SJS/TEN Continuous spectrum or Different entity? 多型性紅斑Erythema Multiforme 史帝芬─強生徵候群(SJS) Stevens-Johnson Syndrome 毒性表皮壞死症TEN Toxic Epidermal Necrolysis Target erythema, Blisters, Tender skin, Epidermal detachment, Exfoliation, Multiple Mucosal involvement * EM→SJS(10%)→SJS/TEN→TEN(30%) * Stevens-Johnson Syndrome  Toxic Epidermal Necrolysis Category Incidence per mil-yr Drug related ratio Mortality Primary eruptions (major feature) Isolate vs Confluence Detachment (% BSA) Interface vs Necrosis Systemic symptoms TEN 0.4-1.2 80-95% 25-50% Red edema denuded Confluen