纳米羟基磷灰石壳聚糖载药微球的制备及性能.pdfVIP

42 5 () Vol.42 No.5 2011 5 Journal of Central South University (Science and Technology) May 2011 / 1, 2 1 1 1 (1. 430070 2. 430070) pH=11 W/O − / / 1~10 µm 38.23%54.21%3 d 82% / R318 A 1672−7207(2011)05−1232−06 Preparation and performance of drug-loaded nano-hydroxyapatite/chitosan microspheres 1, 2 1 1 1 LI Xiang-nan , CHEN Xiao-ming , PENG Zhi-ming , LI Shi-pu (1. Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, China; 2. College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China) Abstract: Nano-hydroxyapatite and chitosan were selected as matrix to prepare a novel metronidazole sustained release microsphere for bone tissue recovery. Aciform nano-hydroxyapatite was synthesized in ethanol medium (pH=11) using polyacrylic acid as dispersant. Metronidazole-loaded chitosan/hydroxyapatite composite microspheres were prepared by water in oil emulsion cross-linking method. The results show that the size of as-fabricated composite microspheres is mainly distributed from 1 to 10 µm, and hydroxyapatite and metronidazole are embedded very well by chitosan. The average drug loading is 38.23%, the average entrapment efficiency is 54.21%, and the cumulative release rate to metronidazole is near 82% during 3 d. The composite microspheres are spherical and distributed uniformly in diameter with