微生态制剂的进展与临床应用评价.pdfVIP

微生态制剂的进展与临床应用评价 刘东红(北京市药品监督管理局东城分局，北京市100007) 中图分类号 R975 文献标识码 A 文章编号 1672—2124(2006)03—0139—04 摘 要 目的：源于上世纪初的微生物理论而于近年发展的微生态制剂在临床上广泛应用，借以调整微生态失调，保持生态平衡， 促进内环境的稳定，控制某些感染性、茵群生态失调、菌群定位转移所相关的多种胃肠道疾病。本文剖析此类药物的分类、作用、 评价和应用原则，为临床提供较为丰厚的信息。方法：综述国内外医药学文献。结果及结论：鉴于微生态制剂上市历程尚短，对其 药动学、体内过程、临床疗效等参数，迄今为止的报道甚少，尚有待于循证医学的多中心、大样本的研究结果所证实。 关键词 微生态制剂；益生茵；腹泻；肠应激综合征；进展 TheAdvancementof andItsClinical Evaluation Microecologicals Application LIU 100007) Donghong(BeijingDongChengDrugAdministration，Beijing ABSTRACT inrecent but fromthe at OBJECTIVE：The microecologicals，developedyearsoriginated microorganismtheory the oflast been usedintheclinicto disturbance，maintain beginningcentury，havewidely regulateecological ecological ofinternal difierent disordersassociatedwithsomeinfe·ctive milieu，control balance，promotestability gastrointestinal flora shiftoffloraorientation．Theofthis isto the imbalance，and ecological purpose paper analyze intheevaluationand of SOasto moreinformationforthereference effects，andprinciples applicationmicroecologicalsprovide of bothhomeandabroad was clinic．METHODS：Literature pharmacy concerning little doneonits viewoftheshort of researchhasbeen marketing microecologicals，and in andclinical remainstobeverifiedmulti—centerand research evidence disposition efficacy，ityet by largesample findings basedmedicine． KEYWORDS