Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia_nihms-474709.pdf

NIH Public Access Author Manuscript N Engl J Med . Author manuscript; available in PMC 2014 June 16. N Published in final edited form as: I H N Engl J Med . 2013 April 18; 368(16): 1509–1518. doi:10.1056/NEJMoa1215134. - P A A u Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid t h o r Leukemia M a n # # Stephan A. Grupp, M.D., Ph.D. , Michael Kalos, Ph.D. , David Barrett, M.D., Ph.D., Richard u s Aplenc, M.D., Ph.D., David L. Porter, M.D., Susan R. Rheingold, M.D., David T. Teachey, c r i p M.D., Anne Chew, Ph.D., Bernd Hauck, Ph.D., J. Fraser Wright, Ph.D., Michael C. Milone, t M.D., Ph.D., Bruce L. Levine, Ph.D., and Carl H. June, M.D. Childrens Hospital of Philadelphia (S.A.G., D.B., R.A., S.R.R., D.T.T., B.H., J.F.W.); the Department of Pediatrics (S.A.G., D.B., R.A., S.R.R., D.T.T.), Abramson Cancer Center (S.A.G., M.K., R.A., D.L.P., S.R.R., D.T.T., M.C.M., B.L.L., C.H.J.); and the Departments of Pathology and Laboratory Medicine (M.K., A.C., B.H., J.F.W., M.C.M., B.L.L., C.H.J.) and Medicine (D.L.P.), N University of Pennsylvania — all in Philadelphia. I H # - These authors contributed equally to this work. P A A Summary u t h Chimeric antigen receptor–modified T cells with specificity for CD19 have shown promise in the o r treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric M a antigen receptor T cells have clinical activity in acute lymphoblastic leukemia (ALL). Two n u children wit