哮喘与慢性阻塞性肺疾病支气管改变的HRCT定量研究-第三军医大学学报.docVIP

哮喘与慢性阻塞性肺疾病支气管改变的HRCT定量研究 （400037 重庆第三军医大学新桥医院放射科） 目的 通过对哮喘和慢性阻塞性肺疾病COPD）患者高分辨率CT（high resolution computed tomography, HRCT）扫描，探讨哮喘和COPD患者段和亚段支气管重塑的差异。 哮喘例COPD 32例正常对照24例，HRCT扫描采用支气管自动分析软件Thoracic VCAR测量壁厚度（wall thickness, WT）、腔内径（inner diameter, Din）壁面积（wall area, WA）和分析组间各指标的差异。结果 哮喘和COPD表现为支气管壁增厚管腔变窄哮喘和COPD段支气管各参数的组间比较WT和WA无统计学差异（P＞0. 05）；哮喘DinCOPD（P0.05）COPD（P0.05）。哮喘和COPD亚段支气管各参数的组间比较（P0.05）（P0.05）结论 哮喘和COPD表现为支气管壁增厚管腔变窄哮喘患者的段和亚段支气管，COPD患者的 [关键词] 支气管哮喘；；高分辨率CT；uantitative study of bronchus changes in asthma and chronic obstructive pulmonary disease by HRCT Zhang Xusheng 1, Zou Liguang 1, Bai Li 2, Zhang Song 1, Wang Changzheng 2, Liang Kaiyun 1 ( 1 Department of Radiology, 2 Department of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China) [Abstract] Objective To investigate airway remodeling differences of segmental bronchi and sub-segmental bronchi between bronchial asthma and chronic obstructive pulmonary disease (COPD) patients by high resolution computed tomography (HRCT). Methods HRCT were performed in 34 asthmatic patients, 32 COPD patients and 24 normal subjects. CT images of segmental bronchi and sub-segmental bronchi were reviewed quantitatively and descriptively. Wall thickness (WT), inner diameter (Din), wall area (WA), percentage of wall area (WA%) of upper lobe apical segmental and sub-segmental bronchi of right and left lung, as well as lower lobe posterior basal segmental and sub-segmental bronchi of right and left lung were detected by bronchus automatic analysis software Thoracic VCAR. The mean values of the four parameters were calculated and the differences of these parameters between groups were analyzed. Results Bronchial wall thickening and luminal narrowing were found in asthma and COPD patients, and bronchiectasis in some cases. The comparison of segmental bronchi parameters between asthma and COPD patients: there was no difference of WA and WA between two groups (P＞0. 05) of