MGB激活调控大鼠初级听皮层神经元反应的细胞机制-生理学专业毕业论文.pdfVIP

第三军医大学硕士学位论文 medial geniculate body (MGBv) placed in the core of the specific sensory pathway, and its activation could evoke tone-specific plasticity in A1 for adjusting different auditory signal processing. However, there is still a distant way to know how the thalamocortical projection contributes to the modulatory mechanisms of various properties of neural reactions and plasticity of cortical neurons. This may partly result from the complex connections, changeable states and diverse characteristics of responses in cortical neurons. Moreover, those previous investigations all adopted extracelluar recording method. For these reasons, they could only identify the existence of the effects of thalamic activations and the tending direction of the cortical plastisity, but couldn’t reveal the electrophysiological mechanism of the contribution of thalamic activation to the auditory information processing in A1 from the level of cellular membrane potential. The clarity of this mechanism will provide the oretical support for our further studies on learning induced or experience-dependent cortical plasticity and will advance our understanding of the biological nature of the information processing in sensory cortex. Therefore, we used intracellular recording technique with sharp glass electrode to make further demonstration. We recorded the membrane potentials of neurons during autonomous state in different cortical layers of rats in vivo, as well as the intracellular membrane characteristics of the excitatory and inhibitory responses to acoustic stimuli of the A1 neurons. We also focused on the changes of the excitatory and inhibitory responses to paired sound stimuli of the A1 neurons induced by thalamic activati