硅溶胶对盐酸万古霉素吸附和缓释的体外研究-第三军医大学学报.docVIP

硅溶胶对盐酸万古霉素吸附和缓释的体外研究 龚滨 熊雁 王子明 王爱民 (第三军医大学大坪医院野战外科研究所骨科,重庆400042) 摘要: 目的 探讨硅溶胶对盐酸万古霉素(VCM)的吸附和体外释放性能，期望能为临床上预防以及治疗开放性骨折和假体置换术后细菌感染提供一种途径。方法 以单分散性好、亲水性强的二氧化硅（SiO2）溶胶为药物载体,用常压低温干燥法制备负载盐酸万古霉素的载药硅溶胶（VCM-SOL）。通过扫描电镜（SEM）、红外光谱分析仪（FT-IR） %）和载药量（42.0 %）,体外释放速度缓慢，8d内释放90.36﹪。结论 常温下制作的硅溶胶对盐酸万古霉素有良好的吸附和体外缓释特性，作为药物载体是可行的。 关键词: 盐酸万古霉素;硅溶胶; 吸附; 缓释 　中图法分类号:R978.1; R318.08 文献标识码: A Adsorption and release of vancomycin hydrochloride from silica sol in vitro GONG Bin，XIONG Yan，WANG Zi-ming, WANG Ai-min (Department of Orthopedics, Daping Hospital, Institute of Surgery Research, Third Military Medical University, Chongqing 400042, China) Abstract: Objective To research the adsorption and release of vancomycin from silica sol in vitro, we hope to provide a way to prevent and treat bacterial infection after surgery of open fractures and prosthesis replacement. Methods The vancomycin -loaded silica sol can be cryodried by incorporation of vancomycin into the monodisperse and hydrophilic sols under the normal pressure. The microstructure and surface group of the vancomycin -loaded silica sol and the unloaded were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The adsorption of vancomycin on silica sol at room temperatures processed was investigated, and the in vitro release rate of vancomycin hydrochloride from silica sol was studied by ultraviolet-visible spectrophotometry．Results The microstructure and surface group of the silica sol was changed after be vancomycin -loaded, indicate that the vancomycin was adsorbed in the silica sol .The adsorption rate and The drug loading amount were (78.67％) and (42.0 %).The in vitro release was a lower rate; the drug release reached 90.36% at the 8th day. Conclusion The Room temperature processed silica sol has good properties including adsorption and release for vancomycin in vitro; it is feasible to be used as drug carriers. Key words：vancomycin hydrochloride ；silica sol；adsorp