MR医学影像文献Rong-2016-Magnetic immunoassay for cancer biom.pdfVIP

Biosensors and Bioelectronics 84 (2016) 15–21 Contents lists available at ScienceDirect Biosensors and Bioelectronics journal homepage: /locate/bios Magnetic immunoassay for cancer biomarker detection based on surface-enhanced resonance Raman scattering from coupled plasmonic nanostructures Zhen Rong a,1, Chongwen Wang a,c,1, Junfeng Wang d, Donggen Wang b,n, Rui Xiao a,n, Shengqi Wang a,n a Beijing Institute of Radiation Medicine, Beijing 100850, PR China b Institute of Transfusion Medicine, Beijing 100850, PR China c College of Life Sciences Bio-Engineering, Beijing University of Technology, Beijing 100124, PR China d College of Mechatronics and Automation, National University of Defense Technology, Changsha 410073, PR China a r t i c l e i n f o a b s t r a c t Article history: A surface-enhanced resonance Raman scattering (SERRS) sensor was developed for the ultrasensitive Received 4 February 2016 detection of cancer biomarkers. Capture antibody-coated silver shell magnetic nanoparticles (Fe O @Ag 3 4 Received in revised form MNPs) were utilized as the CEA enrichment platform and the SERRS signal amplification substrate. Gold 23 March 2016 nanorods (AuNRs) were coated with a thin silver shell to be in resonance with the resonant Raman dye Accepted 4 April 2016 diethylthiatricarbocyanine iodide (DTTC) and the excitation wavelength at 785 nm. The silver-coa