MR医学影像文献She-2016-Differentiating Hemangioblastomas fro.pdfVIP

ORIGINAL RESEARCH ADULT BRAIN Differentiating Hemangioblastomas from Brain Metastases Using Diffusion-Weighted Imaging and Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted MR Imaging X D. She, X X. Yang, X Z. Xing, and X D. Cao ABSTRACT BACKGROUND AND PURPOSE: On DWI and DSC-PWI, hemangioblastomas and brain metastases may exhibit different signal intensities depending on their cellularity and angiogenesis. The purpose of this study was to evaluate whether a hemangioblastoma can be differ- entiated from a single brain metastasis with DWI and DSC-PWI. MATERIALS AND METHODS: We retrospectively reviewed DWI, DSC-PWI, and conventional MR imaging of 21 patients with hemangio- blastomas and 30 patients with a single brain metastasis. Variables of minimum ADC and relative ADC were acquired by DWI and the parameter of relative maximum CBV, by DSC-PWI. Minimum ADC, relative ADC, and relative maximum CBV values were compared between hemangioblastomas and brain metastases by using the nonparametric Mann-Whitney test. The sensitivity, specificity, positive and negative predictive values, accuracy, and the area under the receiver operating characteristic curve were determined. RESULTS: Both the minimum ADC values and relative ADC ratios were significantly higher in hemangioblastomas compared with brain metastases (P .001 for both minimum ADC values and relative ADC ratios). The same was true for the relative maximum CBV ratio (P .002). The threshold value of 6.59 for relativ