MR医学影像文献Zhang-2016-Comparison of rescue techniques for.pdfVIP

Pediatric Anesthesia ISSN 1155-5645 OR IGINAL ARTICLE Comparison of rescue techniques for failed chloral hydrate sedation for magnetic resonance imaging scans—additional chloral hydrate vs intranasal dexmedetomidine Wenhua Zhang, Zixin Wang, Xingrong Song, Yanting Fan, Hang Tian Bilian Li Department of Anesthesiology, Guangzhou Women Children’s Medical Center, Guangzhou, China What is already known • Dexmedetomidine, a highly selective a-2 agonist, has better pharmacokinetic properties than chloral hydrate; however, the efficacy of intranasal dexmedetomidine with that of a second oral dose of chloral hydrate for rescue sedation during magnetic resonance imaging (MRI) studies in infants is unknown. What this article adds • Intranasal dexmedetomidine at a dosage of 1 or 2 mcgkg1 was used successfully for rescue sedation in place of an additional dose of chloral hydrate, in 1- to 6-month-old infants in whom initial chloral hydrate failed during the MRI study. • Intranasal dexmedetomidine appears to cause rescue sedation in a dose-dependent manner. Keywords Summary dexmedetomidine; intranasal administration; deep sedation; chloral Background: Chloral hydrate, a commonly used sedative in children during hydrate noninvasive diagnostic procedures, is associated with side effects like pro- longed sedation, paradoxical excitement, delirium, and unpleasant taste. Correspondence Dexmedetomidine, a highly selective a-2 agonist, has better pharmacokinetic Xingrong Song, Department of properties than chloral hydrate. We conducted this prospective, double-blind, Anaesthesiology, Guangzhou Women ra