MR医学影像文献Zhang-2016-Functionalized magnetic nanochains.pdfVIP

Colloids and Surfaces B: Biointerfaces 140 (2016) 437–445 Contents lists available at ScienceDirect Colloids and Surfaces B: Biointerfaces j o u r n a l h o me p a g e : w w w. elsev /locate/cols urfb Functionalized magnetic nanochains with enhanced MR imaging: A novel nanosystem for targeting and inhibition of early glioma Yi Zhang a , Zhongbing Huang a,∗ , Zhi Wu a , Guangfu Yin a , Lei Wang b , Fabao Gao b,∗∗ a College of Materials Science and Engineering, Sichuan University, China b Molecular Imaging Centre, Department of Radiology, West China Hospital of Sichuan University, 610093, China a r t i c l e i n f o a b s t r a c t Article history: Absence of efficient targeting limits the application of magnetic nanochains (NCs) in the diagnosis of early Received 23 November 2015 brain cancer. Herein, dextran-coated NCs (more than 100 nm length and ∼10 nm cores diameter), which Received in revised form 1 January 2016 were modified by cyclic pentapeptide c(RGDyC) or chlorotoxin (CTX) as the targeting molecules, were Accepted 3 January 2016 fabricated via carbodiimide chemistry and thiol technique. The analysis results revealed that the obtained Available online 6 January 2016 slender NCs exhibited good biocompatibility, superparamagnetic property, high transverse relaxivity (R2 ) and longer blood circulation time. The test results of human umbilical vein endothelial cells and Keywords: U251 human glioma cells indicated