瘦素受体基因gln223arg多态性与代谢综合征的-国家心血管病中心.pdfVIP

中国循环杂志 2016 年 2 月 第 31 卷 第 2 期（总第 212 期）Chinese Circulation Journal，February，2016，Vol. 31 No.2（Serial No.212） 127 临床研究 瘦素受体基因 Gln223Arg 多态性与代谢综合征的相关性及其 对心脏结构功能的影响 陈海翎，王倩，李菊芬，邓丽丽 摘要 目的：探究瘦素受体基因 Gln223Arg 多态性与代谢综合征的相关性及其对心脏结构功能的影响。 方法：研究对象为 2005-10 至 2008-06 我院门诊初诊未治疗的 167 例代谢综合征患者 ( 代谢综合征组 ) 和 216 例 健康体检者 ( 对照组 )。测量血压、生化指标、胰岛素及超声心动图等，限制性片段长度多态性聚合酶链（PCR-RFLP） 法分析 Gln223Arg 基因多态性和测序验证基因型。 结果： 代谢综合征组携带 A 等位基因频率明显高于对照组，携带 A 等位基因者发生代谢综合征的几率是携带 G 等位基因的 3.302 倍 [P =0.000；95% 可信区间（CI）: 2.432~4.483]。初诊而未治疗的代谢综合征患者已出现左心室肥厚 重构和舒张功能减低。代谢综合征组携带 A 等位基因的患者较携带 G 等位基因者有更高的体重指数、血压、血糖和 空腹胰岛素水平 , 更大的腰围，更严重的血脂紊乱、胰岛素抵抗、左心室肥厚及舒张功能减低。 结论：瘦素受体基因 Gln223Arg 多态性 A 等位基因携带者发生代谢综合征的风险较大，更倾向于发生左心室肥厚。 关键词 受体 , 瘦素；多态性 , 单核苷酸；肥大，左心室；代谢综合征 Relationship Between Leptin Receptor Gene Gln223Arg Polymorphism and Metabolism Syndrome With its Impact on Left Ventricular Hypertrophy CHEN Hai-ling, WANG Qian, LI Ju-fen, DENG Li-li. Department of Endocrinology, Beijing Jishuitan Hospital, Beijing (100035), China Corresponding Author: CHEN Hai-ling, Email: hailing_chen@263.net Abstract Objective: To explore the relationship between 1eptin receptor gene Gln223Arg polymorphism and metabolism syndrome (MS) with its impact on cardiac structure and function. Methods: Our research included 2 groups: MS group, n=167 patients with first diagnosed MS without treatment in our hospital from 2005-10 to 2008-6 and Control group, n=216 healthy subjects from regular physical examination. Blood pressure, biochemical features, insulin levels and echocardiography were detected; leptin receptor Gln223Arg genotypes were measured by PCR-RFLP; the above indexes were compared between 2 groups. Results: The patients in MS group had the higher frequency of A allele than Control group. The MS occurrence rate in allele A carr