应用广义多因子降维法分析数量性状的交互作用-中华流行病学杂志.PDF

·938- ·基础理论与方法- 应用广义多因子降维法分析数量性状的 交互作用 陈卿唐迅胡永华 【导读】介绍广义多因子降维法(GMDR)在交互作用分析，尤其是数量性状的基因一基因交 互作用分析中的应用。文中简述GMDR的原理、基本步骤及其特点，并结合实例说明如何在研究 中对GMDR进行应用。GMDR是无模型的交互作用分析方法，能够处理连续型结局变量，还可纳 入协变量改善预测准确率，目前已成功应用于尼古丁依赖等疾病的研究。GMDR能够处理多种 样本类型和结局变量类型，与其他连续变量交互作用分析方法相比具有一定优势。 【关键词】广义多因子降维法；数量性状；交互作用 interactionfor trait muitifactor reduction Detecting quantitativebygeneralized dimensionality and CHEN Xun，HU Biostatistics，SchoolPublic Qi增，TANG yo，lg—hua．DepartmentofEpidemiology of 100191， Health，PekingUniversity，theKeyLaboratoryofEpiderrtiology胧廊竹ofEducation，Be折ng China author：HU CorrespondingYong-hua．Email：yhhu@bjmu．edu．cn NaturalScienceFoundation theNational 死厶work懈supportedbygrantsfrom ofCh／na(No andthe Education SpecializedResearch凡蒯加池DoctoralProgramofHigher (No．20060001111)． Toin舡oducethe of multifactor 【Introductionl applicationgeneralized dimensionality for interactionsfor reduction(GMDR)methoddetectinginteractions，especiallygene—gene aswellasfeaturesofGMDRwere with quantitativetraits．Principles，basicsteps discussed，illustrated a researchcase．Asallinteraction Was for method，GMDRmodel—free，available practical analysis studiesondifferentoutcomevariables continuous for including ones，andpermit=tedadjustment covariatcsto ofits hadbeen researchon improvepredictionaccuracy．Evidencescapacity supposedby different methodWas