肿瘤相关巨噬细胞-药学进展.PDFVIP

PROGRESS IN PHARMACEUTICAL SCIENCES 2015,39 10 :723-733 ( ) 723 肿瘤相关巨噬细胞：在肿瘤演进中的 作用及潜在抗肿瘤靶点 董蓉，袁梦，应美丹，曹戟，杨波 * （浙江大学药学院药理毒理研究所 浙江省抗肿瘤药物临床前研究重点实验室，浙江 杭州 310058） [ 摘要 ] 炎症是公认的肿瘤十大特征之一，而肿瘤相关巨噬细胞是肿瘤微环境的重要组成部分，它影响肿瘤的生长、血管生成、免疫抑制、 转移和药物抗性。最新研究表明，肿瘤相关巨噬细胞还会影响抗肿瘤治疗的临床疗效。鉴于肿瘤相关巨噬细胞在肿瘤演进中起重要作用， 其作为潜在抗肿瘤靶点备受关注。基于最新的研究，对人类癌症中肿瘤相关巨噬细胞的主要功能、作用和特征以及用作新兴肿瘤治疗干预 靶点作一综述。 [ 关键词 ] 肿瘤相关巨噬细胞；肿瘤演进；炎症；细胞因子；巨噬细胞极化；抗肿瘤靶点 [ 中图分类号 ] R966; R962 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2015）10-0723-11 Tumor-associated Macrophages: Critical Role in Tumor Progression and a Potential Antitumor Target DONG Rong, YUAN Meng, YING Meidan, CAO Ji, YANG Bo (Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058,China ) [Abstract] Inflammation is recognized as one of the ten main characteristics of tumors. Tumor associated macrophages (TAMs) are a large component of the tumor microenvironment, which affect tumor growth, angiogenesis, immune suppression, metastasis and chemoresistance. It has been recently suggested that TAMs also affect the clinical efficacy of antitumor therapy. In view of the fact that TAMs play an important role in tumor progression, TAMs as a potential antitumor target have received much attention. Based on the latest researches, the main functions, effects and characteristics of TAMs and their potential as a novel antitumor target were reviewed. [Key words] tumor-associated macrophage; tumor progression; imflammtion; cytokine; macrophage polarization; antitumor target 由于观察到肿瘤往往发生在慢性炎症部位，且肿 白细胞浸润