角膜上皮细胞代的研究进展-中华细胞与干细胞杂志.PDFVIP

( ) 2014 2 4 1 Chin J Cell Stem Cell (Electronic Edition), Feb 2014,Vol. 4, No. 1 72 中华细胞与干细胞杂志电子版 年 月第 卷第 期 •综述• 角膜上皮细胞代�的研究进展 马佰凯 何昕 李炜 【摘要】角膜上皮层位于角膜表面，外邻泪膜，内与角膜前弹力层相连。角膜上皮细胞 代�所需营养及氧分主要通过泪膜、房水和角膜缘毛细血管运送。正常的角膜上皮细胞代 �是维持角膜上皮细胞正常增殖与分化状态的关键。角膜上皮细胞代�异常可导致上皮 损伤或变性，是多种角膜疾病的病理基础。本文就近年来关于角膜上皮细胞代�相关的组 织结构、营养来源、细胞增殖分化以及相关疾病的研究进展进行综述。 【关键词】角膜； 上皮细胞； 代� Research progress in the metabolism of corneal epithelial cells Ma Baikai, He Xin, Li Wei. Medical College of Xiamen University, Xiamen 361102, China Corresponding author: LI Wei, Email: wei1018@xmu.edu.cn Abstract Corneal epithelium is located in the surface layer of the cornea, with tear 【 】 film outside and Bowmans layer inside. The nutrient and oxygen for the metabolism of corneal epithelial cells is transmitted by tear film, anterior aqueous humor and corneal limbal capillary. Metabolism of the corneal epithelial cells is tightly correlated with its proliferation and differentiation. The abnormal metabolism of corneal epithelial cells can cause epithelial damage or dystrophy, which is the pathological basis of many corneal diseases. This review summarizes recent research progress regarding corneal epithelial cell metabolism related tissue structure, origin of nutrient, cell proliferation and differentiation and diseases related to corneal epithelial cell metabolism. Key words Cornea Epithelial cells Metabolism 【 】 ；  ；  4-5 [1-2] 角膜上皮细胞位于角膜外表面，由 层非角 �物质的吸收和交换起重要作用 。角膜基底层 化鳞状上皮细胞组成，在维持眼表稳态以及角膜透 上皮细胞与基底膜、前弹力层的连接主要是借助于 [�-4] 明度中发挥重要作用。正常的角膜上皮细胞代�与 半桥粒等结构而实现的 ，这些连接在维持角膜