蛋白聚糖-2010中.ppt

第三章 蛋白聚糖(proteoglycan);广泛存在的糖胺聚糖和蛋白聚糖;真核生物;结缔组织;皮肤;常见的蛋白聚糖物质;弹性蛋白(Elastin);弹性蛋白(Elastin);糖胺聚糖;蛋白聚糖的结构、功能和代谢;什么是蛋白聚糖？和糖蛋白的区别？;蛋白聚糖的分子组成和分类;糖胺聚糖的类型;GAG的重复单元结构比较;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;肝素与硫酸类肝素的区别;连接区寡糖(1);连接区寡糖(2);Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;核心蛋白的分类;蛋白聚糖核心蛋白的特点;蛋白聚糖的分布、结构和功能;细胞基质型 ;蛋白聚糖的分类(2);透明质酸(hyaluronic acid, HA);能与HA特异相互作用的大分子细胞外CSPG;Aggrecan and Versican;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;细胞外小分子间质蛋白聚糖;细胞外小分子间质蛋白聚糖;基底膜结构;基底膜结构;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;基底膜蛋白聚糖;细胞外基质(extra-cellular matrix,ECM);ECM;GAG链主要是HS，也有CS。 与质膜的结合方式有3种： (1)核心蛋白疏水肽段直接插入膜双层； (2)核心蛋白与GPI共价结合而锚定在质膜上； (3)通过HS链与质膜结合蛋白之间进行特异或非特异相互作用；;细胞表面蛋白聚糖;细胞表面粘附分子;细胞内蛋白聚糖——Serglycin;蛋白聚糖;糖胺聚糖链的生物合成部位;GAG链的合成过程;木糖基是糖胺聚糖链合成的引物;磷酸腺苷磷酸硫酸 (PAPS);HSPG的生物合成;HS biosynthesis involves a series of modification reactions including sulfation and epimerization of GlcA. Chain polymerization and modification are thought to occur simultaneously. ;蛋白聚糖的体内降解;;蛋白聚糖的功能;GAG结合蛋白;范例——肝素与抗凝血;机体内血液凝固、抗凝、纤溶与抗纤溶是相互抑制、相互协调、共同维护血液系统的正常生理功能。;(Red) Oxygen; (gold) sulfur; (blue) nitrogen; (gray) carbon; (white) hydrogen. ;GlcA exists in the 4C1 conformation, where as IdoA exists in equally energetic conformations designated 1C4 and