基于混合方法的免疫t细胞动力学模型研究.pdfVIP

1 Vol.36 No. 1 2008 1 ACTA ELECTRONICA SINICA Jan. 2008 T 莫宏伟 (, 150001) : , . T ,, .T ,T T . : ; ; : TP3016 : A : (2008) Research of Dynamics of Immune T Cells Based on Hybrid Methods O Hongwei ( College of A utomation, H arbin Engineering University, H arbin , H eilongj iang 150001, China) Abstract : Immune system is acomplex selfadaptive system consisting of molecules, cellsand organs.The process of recog nizing,activating,responding to a special antigen is also a process of complex dynamics.In order to understand how dynamics be havior of individual agent propagates to population dynamics, it presents a new method of researching agent population dynamics which is inspired by T cells immuneresponse.The model of T cell agentsisestablished by hybrid model of differential equation and cell automaton. It sets up the base for studying the relation between individual dynamics of T cell and population dynamics of T cells. Key words: immune system dynamics;agent;immuneresponse . 1 . APC T . , TCR. . TCR. . 2 ,, . . , .T (TCR) . .(APC) . T .T ,. .TCR. (ODE) .ODE T TCR.T TCR , . . Lotka , Voltera ,ODEs :(No ;; (No.LC05C03) ; (No.2007RFQXS033) 1 :T 157