靶控输注技术和静脉麻醉.ppt

* If we want to take into account the time lag between plasma concentration change and effect, we can adapt our pharmacokinetic model by adding an effect-site compartment with a negligible distribution volume, but with a rate constant Keo, that is an indicator for the speed of redistribution between the blood and the effect-site compartment. The keo can be calculated for each drug for which we have a measure of the effect. * 异丙酚、咪达唑仑、硫喷妥钠输注1h停药，t1/2cs分别为10min、30min、75min；输注3h停药，t1/2cs分别为15min、50min、100min； * * * 靶控输注技术和静脉麻醉 静脉给药方法：单次和重复静脉注射 效应室浓度 血浆浓度 治疗窗（Therapeutic Window） 不能维持麻醉药的有效浓度；重复给药