大孔吸附树脂在天然产物分离纯化中的应用.PDF

·2764 · 中草药 Chinese Traditional and Herbal Drugs 第 47 卷 第 15 期 2016 年 8 月 大孔吸附树脂在天然产物分离纯化中的应用 1 2 3 1* 1* 刘 丹 ，吴叶红 ，李玮桓 ，张丽 ，史清文 1. 河北医科大学药学院 天然药物化学教研室，河北 石家庄 050017 2. 开滦总医院 药剂科，河北 唐山 063000 3. 华北理工大学附属医院 药学部，河北 唐山 063000 摘 要：大孔树脂是 20 世纪 60 年代末发展起来的一类有较好吸附性能的有机高聚物吸附剂。大孔树脂吸附技术在医药领域 有着较为重要的应用，近年来，其已广泛应用于中药有效成分的提取、分离、纯化工艺。分别从中药或天然药物中活性单体 成分的分离纯化、中药复方制剂的分离纯化，以及树脂混用和联用技术 3 个方面介绍大孔吸附树脂应用，为大孔吸附树脂在 药用植物有效成分分离和复方制剂的纯化中的应用提供参考。 关键词：大孔树脂；吸附；分离纯化；天然产物；吸附剂 中图分类号：R284 文献标志码：A 文章编号：0253 - 2670(2016)15 - 2764 - 07 DOI: 10.7501/j.issn.0253-2670.2016.15.028 Application of macroporous adsorptive resins in separation and purification of natural products 1 2 3 1 1 LIU Dan , WU Ye-hong , LI Wei-huan , ZHANG Man-li , SHI Qing-wen 1. Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China 2. Department of Pharmacy, Kailuan General Hospital of Hebei Province, Tangshan 063000, China 3. Department of Pharmacy,the Affiliated Hospital of North China Institute of Technology University, Tangshan 063000, China Abstract: Macroporous adsorptive resin is a class of organic polymer adsorbent which has good adsorption properties, developed in the late 1960s. The adsorption technology of macroporous adsorptive resin has more and more important application in the field of medicine. Recently, it has been widely used in the extraction, separation, and purification processes of the active ingredients of herbal. This paper reviewed the applications of macroporous adsorptive resin in the isolation and purification of the active monomer components from Chinese materia medica and the mixed and combined application of resin, so as to provide th