Measles麻疹英文课件.pptVIP

MEASLES RUBEOLA OR MORBILLI Department of infectious disease WANG JINGYAN DEFINITION Measles is an acute highly contagious viral disease caused by measles virus.It is characterized by fever,URT catarrhal inflamation, koplik’s spots and maculopapules. The disease may complicated with branch- pneumonia, encepholitis, hepatitis. The lived attenuated measles virus vaccine has been utilized wildly since 1965 ,the incidence of the disease has declined in china. ETIOLOGY 1 .Pathogen is measles virus. it has been classed as a paramyxovirus.it is spherical in appearance ,measuring about 100~150nm in diameter.It has an outer envelope composed of M-protein, H-protein, F-protein, and internal core is RNA. 2 .Site of the measles virus exists measles can be detected from blood and nasal, pharyngeal secretions. ` 3. Three kinds of antibodies are produced after infection,that is 3.1 complement combining antibody; 3.2 hemagglutinin inhibiting antibody 3.3 neutralizing antibody 4 .Only one antigenic type of measles virus is known. 5.Resistance:measles virus is sensitive to heat or disinfectant , it is also inactivated by ultraviolet light easily.not strong EPIDEMIOLOGY 1.Source of infection The patients are the only source of infection. 2 .Routes of transmission air-borne 3. Susceptibility of population 3.1 All age person is susceptible; 90% of contact people acquire the disease. 3.2 The permanent immunity acquire after disease. 4. Epidemic features season:winter and spiring age:6 months to 5 years old PATHOGENESIS AND PATHOLOGY measles virus ↓respiratory tract epithelial cells(multiply) ↓lymphoid tissue blood (first virusemia) ↓