金纳米粒在药物传递系统中的应用-药学进展.PDFVIP

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 4 :285-289 ( ) 285 金纳米粒在药物传递系统中的应用 梁娟娟 1,2 ，耿冬冬 1,2 ，丁娅 1*，张灿 2** (1. 中国药科大学药物质量与安全预警教育部重点实验室，江苏 南京 210009；2. 中国药科大学新药研究中心，江苏 南京 210009) [ 摘要 ] 金纳米粒是一种新型纳米载体，具有独特的理化、光学和生物学性质，且具有低毒性、低免疫原性、生物相容性好、体表面积大、 易制备、粒径和形态可控、表面易修饰等优点，在生物医学领域和药物传递系统中具有广阔的应用前景。综述金纳米粒在小分子药物和基 因药物传递系统中的应用研究新进展。 [ 关键词 ] 金纳米粒；小分子药物；基因药物；药物传递系统 [ 中图分类号 ] R943 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2014）04-0285-05 The Applications of Gold Nanoparticles in Drug Delivery Systems 1,2 1,2 1 2 LIANG Juanjuan , GENG Dongdong , DING Ya , ZHANG Can (1. Key Laboratory of Drug Quality Control and Pharmacovigilance of Ministry of Education, China Pharmaceutical University, Nanjing 210009, China; 2. Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China) [Abstract] Gold nanoparticles (GNPs), a new type of nanometer carrier, show their broad and promising applications in the field of biomedicine and drug delivery systems owing to their unique physicochemical, optical and biological properties as well as their advantages including low toxicity and immunogenicity, good biocompatibility, large surface area, easy preparation, controllable size and shape, flexible surface modification and so on. The recent advances in the applications of GNPs for small molecule drug and gene delivery system were reviewed. [Key words] gold nanoparticle; small molecule drug; gene; drug delivery system