细胞色素P450酶与精神药物氧化代谢课件.pptVIP

;一、P450酶的概述;P450酶命名;P450酶发展史;P450酶分类;P450酶功能;P450酶功能与药物的关系;人体药物氧化代谢的P450酶;P450酶的个体和种族差异（1）;P450酶的个体和种族差异（2）;P450酶的个体和种族差异（3）;药物与P450酶的关系;药物的手性特征;P450酶的饱和性;Content;Abstract;;;Drug withdrawn from US markets due to drug-drug interactions ;; Materials and methods;;Drugs for gastrointestinal diseases;Results;1. Gastric proton pump inhibitors;Figure 1 Chemical structures of five PPIs.;Figure 2 Metabolic differences between four PPIs; ;;2. Histamine H2-receptor antagonists;Figure 3 Chemical structures of six H2-receptor antagonists.;3、Benzamide-type gastroprokinetic agents;Figure 5 Chemical structures of sevenbenzamide-type gastroprokinetic agents.;4. Selective 5-HT3 receptor antagonists;Figure 6 Chemical structures of eight setrons.;;5. Fluoroquinolone;Figure 7 Chemical structures of nine fl uoroquinolones.;Figure 8 Chemical structures of four azole antifungals.;Table 1 Metabolic drug interactions of fl uoroquinolones with clinical relevance;Figure 8 Chemical structures of four azole antifungals.;增强药物代谢的因素;结束语;谢谢